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Predictions › United States › St. Louis Cardinals vs Milwaukee Brewers
MLBFri 25 Sept, 19:40 United States time

St. Louis Cardinals vs Milwaukee Brewers prediction

American Family Field

St. Louis CardinalsAway
4.1 : 5.6
projected runs
Milwaukee BrewersHome
34%Cardinals
66%Brewers
Eagle safe pickOver 7.5 runs
-246

Quick answer

Our prediction for St. Louis Cardinals vs Milwaukee Brewers is Milwaukee Brewers to win, with a 66% chance. We project St. Louis Cardinals 4.1 and Milwaukee Brewers 5.6. Our best bet is Over 7.5 runs at -246.

Prediction
Milwaukee Brewers to win
Chance
66%
Projected score
St. Louis Cardinals 4, Milwaukee Brewers 6
Projected total
9.8 runs
Best bet
Over 7.5 runs at -246

Note: This is our view from the numbers, not a sure thing. One injury, one turnover or one late score can change any game.

The eagle's three picks

✓

Eagle safe pick

Over 7.5 runs
71% chanceFair price -2461 unit
⚡

Eagle bold pick

Cardinals to win
32% chanceFair price +2141 unit

Note: Safe is the bet most likely to win. Value is where the price pays more than it should. Bold pays more but loses more often. A unit is your normal stake.

Why we think this

  1. 1
    What our numbers say

    The model gives Milwaukee Brewers 66% and St. Louis Cardinals 34%. There are no bookmaker prices yet, so this is our model on its own.

  2. 2
    Recent form

    Milwaukee Brewers won 4 of their last 5 and St. Louis Cardinals won 3 of their last 5. Milwaukee Brewers come in with the better run.

  3. 3
    Home and away

    Milwaukee Brewers won 7 of their last 10 games at home. St. Louis Cardinals won 4 of their last 10 on the road.

  4. 4
    Scoring

    Milwaukee Brewers score 6.5 runs a game and let in 4.9. St. Louis Cardinals score 5.2 and let in 5.5. Their recent games average 11.4 and 10.7 runs in total.

  5. 5
    Head to head

    In the last 5 meetings, Milwaukee Brewers won 4 and St. Louis Cardinals won 1. The last one ended St. Louis Cardinals 4, Milwaukee Brewers 8.

  6. 6
    The safest bet

    Over 7.5 runs has a 71% chance, the highest of the bets worth taking here.

Note: Every reason here comes from real results and real prices. We do not guess and we do not copy tipsters.

What moved our number

Eagle 2.0 starts from results and prices, then reads four more things. Here is every change it made on this game.
  • Brewersrest between games-2%
  • Cardinalsrest between games-5%
Corrected using our own settled bets

Note: Each reading is capped on purpose. Together they can never move an expected goal number by more than 12 percent. See the full method.

Match preview

St. Louis Cardinals vs Milwaukee Brewers: Milwaukee Brewers are favourites

By the EagleEyeOdds desk

The big picture

Milwaukee Brewers host St. Louis Cardinals in the MLB on Fri 25 Sept, 19:40 at American Family Field. Our prediction for St. Louis Cardinals vs Milwaukee Brewers is Milwaukee Brewers to win, with a 66% chance. We project St. Louis Cardinals 4.1 and Milwaukee Brewers 5.6. Our best bet is Over 7.5 runs at -246.

Milwaukee Brewers form

Milwaukee Brewers have 12 wins and 8 losses in their last 20 games, with 130 runs scored and 98 conceded. At home they have 7 wins and 3 losses from 10. Their last 5 results read L, W, W, W, W, newest first.

St. Louis Cardinals form

St. Louis Cardinals have 9 wins and 11 losses in their last 20 games, with 104 runs scored and 110 conceded. Away from home they have 4 wins and 6 losses from 10. Their last 5 results read W, W, L, W, L, newest first.

Head to head

These two have met 5 times in our records. Milwaukee Brewers won 4, St. Louis Cardinals won 1. Last time out it finished St. Louis Cardinals 4, Milwaukee Brewers 8.

Our call

We expect St. Louis Cardinals to score about 4.1 runs and Milwaukee Brewers about 5.6. That points to Milwaukee Brewers to win. Our safest bet is Over 7.5 runs at -246. Our bold bet is Cardinals to win at +214.

Note: This preview is written from our data and updates as new results and prices come in.

Team records

Last 20 games in all competitions.

BrewersCardinals
Games played2020
Wins129
Losses811
Runs scored130104
Runs conceded98110
Scored per game6.55.2
Conceded per game4.95.5
Home record7W 3L5W 5L
Away record5W 5L4W 6L

Note: W is a win and L a loss. A team with more games at home or away can look better or worse than it is.

Spread and total at every line

Brewers spreadCoversFair
Brewers -3.532%+213
Brewers -2.541%+145
Brewers -1.550%-101
Brewers -0.560%-148
Brewers +0.569%-218
Total runsOverUnder
7.569%31%
8.561%39%
9.552%48%
10.543%57%
11.534%66%

Note: A spread gives one team a head start. Brewers +3.5 wins if Brewers win or lose by 3 or fewer. If the result lands exactly on the line, your stake comes back.

Latest news on these teams

All news
MLB

Milwaukee Brewers Clinch Playoff Berth After Crushing Cincinnati Reds

The Milwaukee Brewers secured a postseason spot with a dominant 20-0 victory over the Cincinnati Reds on Friday.

12 Sept 2026

Questions people ask

Who will win St. Louis Cardinals vs Milwaukee Brewers?

Our prediction for St. Louis Cardinals vs Milwaukee Brewers is Milwaukee Brewers to win, with a 66% chance. We project St. Louis Cardinals 4.1 and Milwaukee Brewers 5.6. Our best bet is Over 7.5 runs at -246.

What is the projected score for St. Louis Cardinals vs Milwaukee Brewers?

We project St. Louis Cardinals 4.1 and Milwaukee Brewers 5.6, about 9.8 runs in total.

How are Milwaukee Brewers playing?

Milwaukee Brewers have 12 wins and 8 losses in their last 20 games, with 130 runs scored and 98 conceded. At home they have 7 wins and 3 losses from 10. Their last 5 results read L, W, W, W, W, newest first.

How are St. Louis Cardinals playing?

St. Louis Cardinals have 9 wins and 11 losses in their last 20 games, with 104 runs scored and 110 conceded. Away from home they have 4 wins and 6 losses from 10. Their last 5 results read W, W, L, W, L, newest first.

What happened when Milwaukee Brewers and St. Louis Cardinals last met?

It ended St. Louis Cardinals 4, Milwaukee Brewers 8. In the last 5 meetings Milwaukee Brewers won 4 and St. Louis Cardinals won 1.

What is the best bet for St. Louis Cardinals vs Milwaukee Brewers?

Over 7.5 runs at -246, with a 71% chance.

Note: Answers change as prices move. We check every game again every 30 minutes.

Important, please read before you bet

  • These are opinions, not results. Everything on this page is a probability worked out by a computer model from past games and current prices. No one can know what will happen in Brewers against Cardinals. A pick at 70 percent still loses about 3 times in every 10.
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