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Predictions › United States › San Francisco 49ers vs Atlanta Falcons
NFLSun 25 Oct, 13:00 United States time

San Francisco 49ers vs Atlanta Falcons prediction

Mercedes-Benz Stadium

San Francisco 49ersAway
27.2 : 21.8
projected points
Atlanta FalconsHome
67%49ers
33%Falcons
Eagle safe pick49ers to win
-218

Quick answer

Our prediction for San Francisco 49ers vs Atlanta Falcons is San Francisco 49ers to win, with a 67% chance. We project San Francisco 49ers 27.2 and Atlanta Falcons 21.8. Our best bet is 49ers to win at -218.

Prediction
San Francisco 49ers to win
Chance
67%
Projected score
San Francisco 49ers 27, Atlanta Falcons 22
Projected total
49.0 points
Best bet
49ers to win at -218

Note: This is our view from the numbers, not a sure thing. One injury, one turnover or one late score can change any game.

The eagle's three picks

✓

Eagle safe pick

49ers to win
65% chancePrice -2181 unit

Note: Safe is the bet most likely to win. Value is where the price pays more than it should. Bold pays more but loses more often. A unit is your normal stake.

Why we think this

  1. 1
    What our numbers say

    The model gives Atlanta Falcons 33% and San Francisco 49ers 67%. The bookmakers agree and make San Francisco 49ers the favourite at -218.

  2. 2
    Recent form

    Atlanta Falcons won 2 of their last 5 and San Francisco 49ers won 5 of their last 5. San Francisco 49ers come in with the better run.

  3. 3
    Home and away

    Atlanta Falcons won 2 of their last 8 games at home. San Francisco 49ers won 9 of their last 11 on the road.

  4. 4
    Scoring

    Atlanta Falcons score 21.5 points a game and let in 23.4. San Francisco 49ers score 27.4 and let in 21.7. Their recent games average 44.9 and 49.0 points in total, and the market line is 49.5.

  5. 5
    Head to head

    In the last 1 meeting, Atlanta Falcons won 0 and San Francisco 49ers won 1. The last one ended San Francisco 49ers 20, Atlanta Falcons 10.

  6. 6
    The safest bet

    49ers to win has a 65% chance, the highest of the bets worth taking here.

Note: Every reason here comes from real results and real prices. We do not guess and we do not copy tipsters.

What moved our number

Eagle 2.0 starts from results and prices, then reads four more things. Here is every change it made on this game.
  • Falconsteam news-1%
  • 49ersteam news-4%
Corrected using our own settled bets

Note: Each reading is capped on purpose. Together they can never move an expected goal number by more than 12 percent. See the full method.

Match preview

San Francisco 49ers vs Atlanta Falcons: San Francisco 49ers are favourites

By the EagleEyeOdds desk

The big picture

Atlanta Falcons host San Francisco 49ers in the NFL on Sun 25 Oct, 13:00 at Mercedes-Benz Stadium. Our prediction for San Francisco 49ers vs Atlanta Falcons is San Francisco 49ers to win, with a 67% chance. We project San Francisco 49ers 27.2 and Atlanta Falcons 21.8. Our best bet is 49ers to win at -218.

Atlanta Falcons form

Atlanta Falcons have 9 wins and 11 losses in their last 20 games, with 430 points scored and 468 conceded. At home they have 2 wins and 6 losses from 8. Their last 5 results read L, W, W, L, L, newest first.

San Francisco 49ers form

San Francisco 49ers have 15 wins and 5 losses in their last 20 games, with 547 points scored and 434 conceded. Away from home they have 9 wins and 2 losses from 11. Their last 5 results read W, W, W, W, W, newest first.

Head to head

These two have met 1 time in our records. Atlanta Falcons won 0, San Francisco 49ers won 1. Last time out it finished San Francisco 49ers 20, Atlanta Falcons 10.

Our call

We expect San Francisco 49ers to score about 27.2 points and Atlanta Falcons about 21.8. That points to San Francisco 49ers to win. Our safest bet is 49ers to win at -218.

Note: This preview is written from our data and updates as new results and prices come in.

Team records

Last 20 games in all competitions.

Falcons49ers
Games played2020
Wins915
Losses115
Points scored430547
Points conceded468434
Scored per game21.527.4
Conceded per game23.421.7
Home record2W 6L6W 3L
Away record7W 5L9W 2L

Note: W is a win and L a loss. A team with more games at home or away can look better or worse than it is.

Price check against DraftKings

BetOur chanceFairPriceValue
Falcons to win33%+203+180-7.7%
49ers to win65%-186-218-5.1%
Falcons +4.546%+117-115-13.7%
49ers -4.550%-102-105-1.6%
Over 49.5 points47%+112-110-10.0%
Under 49.5 points49%+102-110-5.7%

Note: Green value means the price pays more than our fair price. We only call it a value pick from 3% up, because small gaps can be noise.

Spread and total at every line

Falcons spreadCoversFair
Falcons -1.530%+231
Falcons +2.541%+143
Falcons +5.550%-100
Falcons +8.559%-143
Falcons +12.570%-231
Total pointsOverUnder
41.572%28%
45.561%39%
48.552%48%
51.542%58%
55.531%69%

Note: A spread gives one team a head start. Falcons +3.5 wins if Falcons win or lose by 3 or fewer. If the result lands exactly on the line, your stake comes back.

Latest news on these teams

All news
NFL

49ers Lose Deebo Samuel as Wide Receiver Injuries Mount

Deebo Samuel will miss at least a couple of games with a hamstring injury, adding to growing depth issues for the 49ers.

12 Oct 2026
NFL

Michael Penix Jr. Suffers Rib Injury in Falcons Overtime Loss

Michael Penix Jr. hurt his ribs late in Atlanta's overtime defeat against Baltimore but expects to return quickly.

12 Oct 2026
NFL

Niners Linebacker Dre Greenlaw Ejected for Headbutt Against Seattle

Dre Greenlaw was thrown out of Sunday's game against Seattle after hitting Sam Darnold late and making face contact with Ernest Jones IV.

11 Oct 2026

Questions people ask

Who will win San Francisco 49ers vs Atlanta Falcons?

Our prediction for San Francisco 49ers vs Atlanta Falcons is San Francisco 49ers to win, with a 67% chance. We project San Francisco 49ers 27.2 and Atlanta Falcons 21.8. Our best bet is 49ers to win at -218.

What is the projected score for San Francisco 49ers vs Atlanta Falcons?

We project San Francisco 49ers 27.2 and Atlanta Falcons 21.8, about 49.0 points in total.

How are Atlanta Falcons playing?

Atlanta Falcons have 9 wins and 11 losses in their last 20 games, with 430 points scored and 468 conceded. At home they have 2 wins and 6 losses from 8. Their last 5 results read L, W, W, L, L, newest first.

How are San Francisco 49ers playing?

San Francisco 49ers have 15 wins and 5 losses in their last 20 games, with 547 points scored and 434 conceded. Away from home they have 9 wins and 2 losses from 11. Their last 5 results read W, W, W, W, W, newest first.

What happened when Atlanta Falcons and San Francisco 49ers last met?

It ended San Francisco 49ers 20, Atlanta Falcons 10. In the last 1 meeting Atlanta Falcons won 0 and San Francisco 49ers won 1.

What is the best bet for San Francisco 49ers vs Atlanta Falcons?

49ers to win at -218, with a 65% chance.

Note: Answers change as prices move. We check every game again every 30 minutes.

Important, please read before you bet

  • These are opinions, not results. Everything on this page is a probability worked out by a computer model from past games and current prices. No one can know what will happen in Falcons against 49ers. A pick at 70 percent still loses about 3 times in every 10.
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