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Predictions › United States › Pittsburgh Panthers vs Louisville Cardinals
College FootballSat 21 Nov, 00:00 United States time

Pittsburgh Panthers vs Louisville Cardinals prediction

L&N Federal Credit Union Stadium

Pittsburgh PanthersAway
25.4 : 37.3
projected points
Louisville CardinalsHome
22%Pitt
78%Louisville
Eagle safe pickLouisville to win
-350

Quick answer

Our prediction for Pittsburgh Panthers vs Louisville Cardinals is Louisville Cardinals to win, with a 78% chance. We project Pittsburgh Panthers 25.4 and Louisville Cardinals 37.3. Our best bet is Louisville to win at -350.

Prediction
Louisville Cardinals to win
Chance
78%
Projected score
Pittsburgh Panthers 25, Louisville Cardinals 37
Projected total
62.8 points
Best bet
Louisville to win at -350

Note: This is our view from the numbers, not a sure thing. One injury, one turnover or one late score can change any game.

The eagle's three picks

✓

Eagle safe pick

Louisville to win
78% chanceFair price -3502 units

Note: Safe is the bet most likely to win. Value is where the price pays more than it should. Bold pays more but loses more often. A unit is your normal stake.

Why we think this

  1. 1
    What our numbers say

    The model gives Louisville Cardinals 78% and Pittsburgh Panthers 22%. There are no bookmaker prices yet, so this is our model on its own.

  2. 2
    Recent form

    Louisville Cardinals won 4 of their last 5 and Pittsburgh Panthers won 2 of their last 5. Louisville Cardinals come in with the better run.

  3. 3
    Home and away

    Louisville Cardinals won 8 of their last 12 games at home. Pittsburgh Panthers won 5 of their last 9 on the road.

  4. 4
    Scoring

    Louisville Cardinals score 33.9 points a game and let in 23.9. Pittsburgh Panthers score 30.9 and let in 23.7. Their recent games average 57.7 and 54.6 points in total.

  5. 5
    Head to head

    In the last 1 meeting, Louisville Cardinals won 1 and Pittsburgh Panthers won 0. The last one ended Pittsburgh Panthers 27, Louisville Cardinals 34.

  6. 6
    The safest bet

    Louisville to win has a 78% chance, the highest of the bets worth taking here.

Note: Every reason here comes from real results and real prices. We do not guess and we do not copy tipsters.

What moved our number

Eagle 2.0 starts from results and prices, then reads four more things. Here is every change it made on this game.

Nothing moved this one. Both teams are rested, form is level and there is no team news we can act on, so the number is what the results and the price say on their own.

Corrected using our own settled bets

Note: Each reading is capped on purpose. Together they can never move an expected goal number by more than 12 percent. See the full method.

Match preview

Pittsburgh Panthers vs Louisville Cardinals: Louisville Cardinals are favourites

By the EagleEyeOdds desk

The big picture

Louisville Cardinals host Pittsburgh Panthers in the College Football on Sat 21 Nov, 00:00 at L&N Federal Credit Union Stadium. Our prediction for Pittsburgh Panthers vs Louisville Cardinals is Louisville Cardinals to win, with a 78% chance. We project Pittsburgh Panthers 25.4 and Louisville Cardinals 37.3. Our best bet is Louisville to win at -350.

Louisville Cardinals form

Louisville Cardinals have 13 wins and 7 losses in their last 20 games, with 677 points scored and 477 conceded. At home they have 8 wins and 4 losses from 12. Their last 5 results read W, W, W, W, L, newest first.

Pittsburgh Panthers form

Pittsburgh Panthers have 12 wins and 8 losses in their last 20 games, with 619 points scored and 474 conceded. Away from home they have 5 wins and 4 losses from 9. Their last 5 results read W, L, L, L, W, newest first.

Head to head

These two have met 1 time in our records. Louisville Cardinals won 1, Pittsburgh Panthers won 0. Last time out it finished Pittsburgh Panthers 27, Louisville Cardinals 34.

Our call

We expect Pittsburgh Panthers to score about 25.4 points and Louisville Cardinals about 37.3. That points to Louisville Cardinals to win. Our safest bet is Louisville to win at -350.

Note: This preview is written from our data and updates as new results and prices come in.

Team records

Last 20 games in all competitions.

LouisvillePitt
Games played2020
Wins1312
Losses78
Points scored677619
Points conceded477474
Scored per game33.930.9
Conceded per game23.923.7
Home record8W 4L7W 4L
Away record5W 3L5W 4L

Note: W is a win and L a loss. A team with more games at home or away can look better or worse than it is.

Spread and total at every line

Louisville spreadCoversFair
Louisville -18.534%+194
Louisville -14.544%+130
Louisville -11.551%-104
Louisville -8.558%-141
Louisville -4.568%-211
Total pointsOverUnder
55.567%33%
59.558%42%
62.551%49%
65.543%57%
69.534%66%

Note: A spread gives one team a head start. Louisville +3.5 wins if Louisville win or lose by 3 or fewer. If the result lands exactly on the line, your stake comes back.

Latest news on these teams

All news
College Football

North Carolina Stuns Pittsburgh in Belichick Upset Win

North Carolina upset No. 25 Pittsburgh 21-17 on Saturday, giving coach Bill Belichick his first victory over a ranked opponent with the team.

10 Oct 2026
College Football

Louisville Rallies Past Florida State After Early Deficit

Florida State blew a 14-0 lead as Louisville scored 44 points to pull away for a dominant victory on Friday.

10 Oct 2026
College Football

Pitt Outlasts Virginia Tech 35-33 to Stay Unbeaten

The Pittsburgh Panthers stayed undefeated with a 35-33 win over Virginia Tech, despite losing starting quarterback Mason Heintschel to injury.

3 Oct 2026

Questions people ask

Who will win Pittsburgh Panthers vs Louisville Cardinals?

Our prediction for Pittsburgh Panthers vs Louisville Cardinals is Louisville Cardinals to win, with a 78% chance. We project Pittsburgh Panthers 25.4 and Louisville Cardinals 37.3. Our best bet is Louisville to win at -350.

What is the projected score for Pittsburgh Panthers vs Louisville Cardinals?

We project Pittsburgh Panthers 25.4 and Louisville Cardinals 37.3, about 62.8 points in total.

How are Louisville Cardinals playing?

Louisville Cardinals have 13 wins and 7 losses in their last 20 games, with 677 points scored and 477 conceded. At home they have 8 wins and 4 losses from 12. Their last 5 results read W, W, W, W, L, newest first.

How are Pittsburgh Panthers playing?

Pittsburgh Panthers have 12 wins and 8 losses in their last 20 games, with 619 points scored and 474 conceded. Away from home they have 5 wins and 4 losses from 9. Their last 5 results read W, L, L, L, W, newest first.

What happened when Louisville Cardinals and Pittsburgh Panthers last met?

It ended Pittsburgh Panthers 27, Louisville Cardinals 34. In the last 1 meeting Louisville Cardinals won 1 and Pittsburgh Panthers won 0.

What is the best bet for Pittsburgh Panthers vs Louisville Cardinals?

Louisville to win at -350, with a 78% chance.

Note: Answers change as prices move. We check every game again every 30 minutes.

Important, please read before you bet

  • These are opinions, not results. Everything on this page is a probability worked out by a computer model from past games and current prices. No one can know what will happen in Louisville against Pitt. A pick at 70 percent still loses about 3 times in every 10.
  • We do not promise profit. Our public record shows wins and losses together, and losing runs happen to every method. Treat any money you stake as money you may never see again.
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