EagleEyeOdds eagleEagleEyeOddsToday's picks
PredictionsBest bets by countryKenyaNigeriaGhanaSouth AfricaUnited KingdomUnited StatesIndiaTanzaniaUgandaZambiaCameroonIvory CoastAll 54 countriesNewsOur recordHow Eagle 2.0 worksResponsible gambling
Predictions › United States › San Francisco 49ers vs Seattle Seahawks
NFLSun 11 Oct, 16:25 United States time

San Francisco 49ers vs Seattle Seahawks prediction

Lumen Field

San Francisco 49ersAway
22.3 : 24.3
projected points
Seattle SeahawksHome
44%49ers
56%Seahawks
Eagle safe pick49ers +10
-290

Quick answer

Our prediction for San Francisco 49ers vs Seattle Seahawks is Seattle Seahawks to win, with a 56% chance, but it is a close call. We project San Francisco 49ers 22.3 and Seattle Seahawks 24.3. Our best bet is 49ers +10 at -290.

Prediction
Seattle Seahawks to win
Chance
56%
Projected score
San Francisco 49ers 22, Seattle Seahawks 24
Projected total
46.6 points
Best bet
49ers +10 at -290

Note: This is our view from the numbers, not a sure thing. One injury, one turnover or one late score can change any game.

The eagle's three picks

✓

Eagle safe pick

49ers +10
74% chanceFair price -2901 unit

Note: Safe is the bet most likely to win. Value is where the price pays more than it should. Bold pays more but loses more often. A unit is your normal stake.

Why we think this

  1. 1
    What our numbers say

    The model gives Seattle Seahawks 56% and San Francisco 49ers 44%. The bookmakers agree and make Seattle Seahawks the favourite at -175.

  2. 2
    Recent form

    Seattle Seahawks won 2 of their last 5 and San Francisco 49ers won 5 of their last 5. San Francisco 49ers come in with the better run.

  3. 3
    Home and away

    Seattle Seahawks won 8 of their last 9 games at home. San Francisco 49ers won 8 of their last 11 on the road.

  4. 4
    Scoring

    Seattle Seahawks score 26.3 points a game and let in 15.8. San Francisco 49ers score 26.5 and let in 21.6. Their recent games average 42.0 and 48.0 points in total, and the market line is 47.5.

  5. 5
    Head to head

    In the last 2 meetings, Seattle Seahawks won 2 and San Francisco 49ers won 0. The last one ended Seattle Seahawks 41, San Francisco 49ers 6.

  6. 6
    The safest bet

    49ers +10 has a 74% chance, the highest of the bets worth taking here.

Note: Every reason here comes from real results and real prices. We do not guess and we do not copy tipsters.

What moved our number

Eagle 2.0 starts from results and prices, then reads four more things. Here is every change it made on this game.
  • Seahawksteam news-1%
Corrected using our own settled bets

Note: Each reading is capped on purpose. Together they can never move an expected goal number by more than 12 percent. See the full method.

Match preview

San Francisco 49ers vs Seattle Seahawks: Seattle Seahawks shade it

By the EagleEyeOdds desk

The big picture

Seattle Seahawks host San Francisco 49ers in the NFL on Sun 11 Oct, 16:25 at Lumen Field. Our prediction for San Francisco 49ers vs Seattle Seahawks is Seattle Seahawks to win, with a 56% chance, but it is a close call. We project San Francisco 49ers 22.3 and Seattle Seahawks 24.3. Our best bet is 49ers +10 at -290.

Seattle Seahawks form

Seattle Seahawks have 15 wins and 4 losses in their last 20 games, with 525 points scored and 316 conceded. At home they have 8 wins and 1 loss from 9. Their last 5 results read L, W, W, D, L, newest first.

San Francisco 49ers form

San Francisco 49ers have 14 wins and 6 losses in their last 20 games, with 530 points scored and 431 conceded. Away from home they have 8 wins and 3 losses from 11. Their last 5 results read W, W, W, W, W, newest first.

Head to head

These two have met 2 times in our records. Seattle Seahawks won 2, San Francisco 49ers won 0. Last time out it finished Seattle Seahawks 41, San Francisco 49ers 6.

Our call

We expect San Francisco 49ers to score about 22.3 points and Seattle Seahawks about 24.3. That points to Seattle Seahawks to win. Our safest bet is 49ers +10 at -290.

Note: This preview is written from our data and updates as new results and prices come in.

Team records

Last 20 games in all competitions.

Seahawks49ers
Games played2020
Wins1514
Losses46
Points scored525530
Points conceded316431
Scored per game26.326.5
Conceded per game15.821.6
Home record8W 1L6W 3L
Away record7W 3L8W 3L

Note: W is a win and L a loss. A team with more games at home or away can look better or worse than it is.

Price check against Draft Kings

BetOur chanceFairPriceValue
Seahawks to win56%-128-175-11.9%
49ers to win38%+163+145-6.7%
Seahawks -344%+127-112-16.5%
49ers +350%-100-108-3.7%
Over 47.5 points45%+125-110-15.0%
Under 47.5 points50%+102-110-5.3%

Note: Green value means the price pays more than our fair price. We only call it a value pick from 3% up, because small gaps can be noise.

Spread and total at every line

Seahawks spreadCoversFair
Seahawks -8.531%+218
Seahawks -4.543%+135
Seahawks -1.551%-106
Seahawks +1.560%-151
Seahawks +5.571%-245
Total pointsOverUnder
39.571%29%
43.560%40%
46.550%50%
49.541%59%
53.530%70%

Note: A spread gives one team a head start. Seahawks +3.5 wins if Seahawks win or lose by 3 or fewer. If the result lands exactly on the line, your stake comes back.

Latest news on these teams

All news
NFL

Sam Darnold Targets Sunday Return After Scary Injury

Seattle Seahawks quarterback Sam Darnold is back at practice and hopes to play this Sunday against the Washington Commanders.

24 Sept 2026
NFL

Brock Purdy and Christian McCaffrey Make History in 49ers Win

Brock Purdy put on a near-perfect display and Christian McCaffrey reached a career milestone as the San Francisco 49ers beat the Dolphins 35-13.

21 Sept 2026
NFL

Seahawks Roll to 2-0 as Darnold Nears Return and Lock Shines

The Seattle Seahawks are 2-0 after a 31-7 win over Arizona, with Sam Darnold recovering quickly and backup Drew Lock playing well.

21 Sept 2026

Questions people ask

Who will win San Francisco 49ers vs Seattle Seahawks?

Our prediction for San Francisco 49ers vs Seattle Seahawks is Seattle Seahawks to win, with a 56% chance, but it is a close call. We project San Francisco 49ers 22.3 and Seattle Seahawks 24.3. Our best bet is 49ers +10 at -290.

What is the projected score for San Francisco 49ers vs Seattle Seahawks?

We project San Francisco 49ers 22.3 and Seattle Seahawks 24.3, about 46.6 points in total.

How are Seattle Seahawks playing?

Seattle Seahawks have 15 wins and 4 losses in their last 20 games, with 525 points scored and 316 conceded. At home they have 8 wins and 1 loss from 9. Their last 5 results read L, W, W, D, L, newest first.

How are San Francisco 49ers playing?

San Francisco 49ers have 14 wins and 6 losses in their last 20 games, with 530 points scored and 431 conceded. Away from home they have 8 wins and 3 losses from 11. Their last 5 results read W, W, W, W, W, newest first.

What happened when Seattle Seahawks and San Francisco 49ers last met?

It ended Seattle Seahawks 41, San Francisco 49ers 6. In the last 2 meetings Seattle Seahawks won 2 and San Francisco 49ers won 0.

What is the best bet for San Francisco 49ers vs Seattle Seahawks?

49ers +10 at -290, with a 74% chance.

Note: Answers change as prices move. We check every game again every 30 minutes.

Important, please read before you bet

  • These are opinions, not results. Everything on this page is a probability worked out by a computer model from past games and current prices. No one can know what will happen in Seahawks against 49ers. A pick at 70 percent still loses about 3 times in every 10.
  • We do not promise profit. Our public record shows wins and losses together, and losing runs happen to every method. Treat any money you stake as money you may never see again.
  • 18 plus only. Betting is for adults. In some countries the legal age is higher and in some it is not allowed at all. You alone are responsible for checking the law where you live.
  • Prices move. The odds shown were read from a bookmaker feed and may already be different. Always check the price in your own account before you place anything.
  • No advice for your money. We are not financial advisers and we do not know your situation. Nothing here is financial advice or a recommendation to stake any amount.
  • Betting can harm you. If it stops being fun, if you chase losses, or if you hide it from people close to you, stop and get help. Free and private support is available from BeGambleAware, GamCare and Gamblers Anonymous. Read our responsible gambling page for tools that block betting sites.

Full terms are on our disclaimer and terms pages.

Note: Never stake money you need for rent, food, bills or anyone who depends on you.